Fig. 6.

Responsiveness of OB and PVZ cells to purinergic receptor agonists. a Mean [Ca²⁺]_i transients (±SEM) of all clearly identifiable responsive cells of an OB (red traces) and a PVZ (green traces). Traces originate from more than one tissue slice. b The mean peak amplitude of agonist-induced responses (±SEM) of cells of the OB and the PVZ were compared (red columns OB cells, green columns PVZ cells). [adenosine (100 μM), data from 170 OB cells and 236 PVZ cells from 6 slices of the anterior telencephalon; ADP (100 μM), 245 OB cells and 154 PVZ cells from three slices; ATP (50 μM), 1566 OB cells and 1303 PVZ cells from 28 and 23 slices, respectively; 2MeSATP (100 μM), 378 OB cells and 285 PVZ cells from five slices; BzATP (50 μM), 213 OB cells and 93 PVZ cells from four and two slices, respectively; α,β-MeATP (50 μM), 310 OB cells and 198 PVZ cells from six and three slices, respectively; β,γ-MeATP (100 μM), 387 OB cells and 318 PVZ cells from seven and six slices, respectively; uridine (100 μM), 275 OB cells and 308 PVZ cells from six slices; UTP (100 μM), 335 OB cells and 324 PVZ cells from five slices]. (*p < 0.05 and **p < 0.01; unpaired t test). Abbreviations: ADP adenosine-5′-diphosphate, ATP adenosine-5′-triphosphate, UTP uridine-5′-triphosphate; α,β-MeATP α,β-methylene-ATP, β,γ-MeATP β,γ-methylene-ATP, 2MeSATP 2-methylthio-ATP, BzATP, 3′-O-(4-benzoyl)benzoyl ATP