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Cleavage of N2N and Notch2 by mutant NE. (A) Recombinant GST-N2N fusion proteins cleaved by recombinant, wild-type, or mutant NE in vitro, as indicated, Coomassie-stained SDS-PAGE. (B) Western blot result of endogenous Notch2 digested by NE in U937 cells when wild-type or mutant NE is added to the culture medium. p-NE- denotes NE produced recombinantly in P. pastoris; c-NE- denotes commercially obtained NE.
