Table 3.
Virus titers in BALF and macroscopic and microscopic lung lesions in influenza virus-inoculated pigs
| Virus | Virus titer in BALF (TCID50/mL)a | Lung lesion score (%)b | Histopathologic score (0–3)b | |||
|---|---|---|---|---|---|---|
| Day 3 p.i. | Day 5 p.i. | Day 3 p.i. | Day 5 p.i. | Day 3 p.i. | Day 5 p.i. | |
| Avian-origin PB2 | ||||||
| Mock | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.40 ± 0.40 | 0.40 ± 0.24 |
| 1930-Tx/98PB2-627E | 3.76 ± 0.51 | 3.92 ± 0.48 | 15.97 ± 4.46 | 14.01 ± 3.10 | 2.90 ± 0.40 | 2.60 ± 0.51 |
| 1930-Tx/98PB2-627K | 5.17 ± 0.55e | 3.65 ± 0.17 | 16.40 ± 3.37 | 9.97 ± 2.17f | 2.60 ± 0.40 | 2.50 ± 0.45 |
| Swine-origin PB2 | ||||||
| Mock | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.70 ± 0.12 | 0.60 ± 0.19 |
| 1930-PB2-627E | 2.96 ± 0.14c, e | 3.99 ± 0.30 | 23.31 ± 4.13 | 10.26 ± 2.29d | 2.40 ± 0.19 | 2.30 ± 0.30 |
| 1930-PB2-627K | 4.25 ± 0.41c | 4.39 ± 0.10 | 24.49 ± 4.08 | 22.29 ± 5.46d, f | 3.00 ± 0.16 | 2.90 ± 0.10 |
a
Values represent the log10 geometric mean BALF TCID50/mL ± SEM
b
Values represent the mean ± SEM
c, d, e, f
There is a significant difference between the 2 groups (P < 0.05)