Table 3.
Quantitative Analysis of Dividing and Apoptotic Cells in Human Ovarian Cancers SKOV3ip1 (A) and IGROV1 (B) Growing in the Peritoneal Cavity of Nude Mice.
| Treatment Group | BrdU* | TUNEL* |
| (A) | ||
| Control | 64.8 ± 20.0 | 6.5 ± 3.2 |
| Paclitaxel, 5 mg/kg | 30.8 ± 14.9† | 150.0 ± 38.3† |
| Macitentan, 50 mg/kg | 48.7 ± 15.1 | 54.7 ± 17.9† |
| Paclitaxel + macitentan | 18.5 ± 11.1† | 195.3 ± 42.6†,‡ |
| (B) | ||
| Control | 55.2 ± 13.9 | 5.7 ± 3.3 |
| Paclitaxel, 5 mg/kg | 28.2 ± 10.0‡ | 139.0 ± 29.7† |
| Macitentan, 50 mg/kg | 45.9 ± 13.4 | 69.0 ± 13.1† |
| Paclitaxel + macitentan | 19.6 ± 8.8† | 181.4 ± 32.9†,‡ |
*
Number of cells in 0.159-mm2 field.
†
Statistically significant compared with the control group (P < .05).
‡
Statistically significant compared with the paclitaxel group (P < .01).