Figure 5.
Activity of zinc ionophores in tumor xenograft models. A, median tumor volume (±SE) over time in nude mice bearing A549 tumors treated with control (5% mannitol) vehicle, PCI-5002 (100 μmol/kg q.d. × 4), or PCI-5003 (100 μmol/kg q.d. × 4) *, P < 0.05, Student's t test. B, median tumor volume (±SE) over time in nude mice bearing A549 tumors treated with control vehicle, PCI-5003 (80 μmol/kg q.d. × 2), or MGd (40 μmol/kg i.p.) + PCI-5003 (80 μmol/kg q.d. × 2) **, P < 0.01, log-rank test, time to 500 mm3. C, median tumor volume (±SE) over time in nude mice bearing PC3 tumors treated with control vehicle, PCI-5002 (100 μmol/kg q.d. × 2), or PCI-5002 (100 μmol/kg q.d. × 4) **, P = 0.02, log-rank test, time to 500 mm3.