Fig. 3.

GO functional analysis for overrepresented biological processes and molecular functions. Statistically significant overrepresented GO categories for both biological processes (A) and molecular functions (B), as a result of the comparison of the neomycin-extracted protein dataset to the murine nucleome reference data set. Each GO category is represented as the ratio between % neomycin (= % of annotated proteins of the whole neomycin set) and % nucleome (= % of annotated proteins of the whole nucleome) and are visualized as black bars (complete list). The gray bars represent the statistically significant overrepresented GO categories when the same analysis was done but with only proteins containing K/R motifs, PH and PHD domains as the test dataset (proteins with PI domain). See Supplemental Figs. S2 and S3 for a visualization as hierarchy networks.