Fig. 3.
In vivo HDAC5 phosphorylation reveals site conservation among class IIa HDACs. A, Location of phosphorylated sites along the HDAC5-EGFP-FLAG sequence. B, Conservation of phosphosites among HDAC5 vertebrate species. NCBI gi numbers used were: Homo sapiens 62750347, Pongo abelii 55730067, Pan troglodytes 114666888, Macaca mulatta 109116100, Bos taurus 194676212, Equus caballus 194216834, Canis familiaris 73965560 (isoform 1), Cricetulus griseus 28627825, Mus musculus 148702151, Rattus norvegicus 109491954, Danio rerio 189517029. The cladogram of vertebrate HDAC5 sequence divergence was generated from NCBI BLASTp by the TreeView program (43).