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. 2010 May 5;151(7):3374–3385. doi: 10.1210/en.2009-1339

Figure 8.

Figure 8

Quantification of histological changes in adult PTM-ARKO seminal vesicles after exposure to T and E2. A, Epithelial cell height (immunostained for cytokeratin, brown) is significantly reduced in PTM-ARKO SVs treated with T+E2, compared with T+E2-treated controls (as reported in untreated mice). Exposure to T+E2 does not result in any change in epithelial cell height, compared with untreated PTM-ARKOs and controls, respectively. B, The depth of the smooth muscle cell layer (immunostained for SMA, brown, *) is significantly smaller in PTM-ARKO SVs treated with T+E2, compared with treated controls. Note that exposure to T+E2 results in a significant increase in this smooth muscle layer in PTM-ARKO and control SVs, compared with untreated PTM-ARKOs and controls, respectively. C, Quantification of epithelial cell mitosis revealed a significant increase in epithelial mitosis in control SVs treated with T+E2, compared with untreated controls. Note that there is significantly more epithelial cell mitosis in PTM-ARKO SVs than controls but that treatment with T+E2 does not significantly alter epithelial cell mitosis in PTM-ARKO mice. Values are means ± sem (n = 3 mice). *, P < 0.05, compared with control littermates or untreated mice; **, P < 0.01, compared with control littermates.