Table 1.

Probabilities and rates of generation of various HCV mutants.

Time	Number of nucleotide changes	Probability	Number of virions generated per day	Number of all possible mutants	Fraction of all possible mutants created per day
Before therapy	0	0.91	9.1×1011
	1	0.087	8.7×1010	2.9×104	1
	2	0.0042	4.2×109	4.1×108	1
	3	0.00013	1.3×108	4.0×1012	3.4×10-5
End of first day of therapy*	0	0.91	9.1×106
	1	0.087	8.7×105	2.9×104	1
	2	0.0042	4.2×104	4.1×108	1.0×10-4
	3	0.00013	1.3×103	4.0×1012	3.4×10-10

^*Additional drug-resistant or compensatory mutation after a 5-log₁₀ decrease in the HCV RNA production during treatment.