A, intracellular NO release after JS-K treatment measured as DAF fluorescence. B, intracellular ROS/RNS level after JS-K treatment measured as DCF fluorescence. A representative experiment is shown (n = 4). a, P < 0.01; b, P < 0.001; c, P < 0.0001, by paired t test, compared with cells treated with DMSO only.