Fig. 7.
Effect of apelin-13 and NADPH oxidase inhibitors on neuronal delayed rectifier K+ current (IKv). IKv was recorded during 250-ms voltage steps from a holding potential of −40 to +10 mV. A and B, representative current tracings of neuronal IKv recorded from neurons under the following sequential treatment conditions: control (Con), superfusion of apelin-13 (100 nM), washout of apelin-13, superfusion of gp91ds-tat (GP, 5 μM) or scrambled gp91ds-tat (Scra, 5 μM), and superfusion of apelin-13 plus GP or Scra. C and D, bar graphs show mean ± S.E. of IKv densities obtained in each treatment condition described in A and B. n = 8 and 6 neurons for GP and Scra group, respectively; *, P < 0.05 compared with control.