Fig. 2.

Dose-dependent effects of N-substituted BZT analogs on locomotor activity in mice. Ordinates: horizontal locomotor activity counts after drug administration as a percentage of control values. Abscissae: dose of drug in milligrams per kilogram log scale. Each point represents the average effect determined in six to eight mice. Vertical bars represent the standard error of the mean. The data are from the 30-min period immediately after drug administration. Note that none of the BZT analogs produced a stimulation of activity that was equivalent to that of cocaine, and that only with JHW 013 was there a trend toward stimulated locomotor activity.