. Author manuscript; available in PMC: 2011 Mar 1.

Published in final edited form as: J Endocrinol. 2009 Dec 23;204(3):241–253. doi: 10.1677/JOE-09-0328

Table 4.

Histomorphometry of Irs1^+/+ and Irs1^sml/sml distal femurs at 13 weeks of age

	+/+ Males	sml/sml Males	+/+ Females	sml/sml Females
% BV/TV	12.09 ± 0.63	7.80 ± 0.08^a	13.47 ± 1.63	6.94 ± 1.24^a
Nob/BPm (/mm)	28.00 ± 1.23	29.82 ± 2.12	27.28 ± 1.52	31.83 ± 1.05^a
Noc/BPm (/mm)	3.70 ± 0.37	4.32 ± 0.77	3.90 ± 0.35	5.75 ± 0.38^a
ES/BS (%)	12.5 ± 1.29	13.58 ± 1.69	12.87 ± 1.22	17.06 ± 0.67^a
MS/BS (%)	6.89 ± 0.51	2.41 ± 0.38^a	7.14 ± 0.84	4.10 ± 0.32^a
MAR (um/day)	0.441 ± 0.026	0.290 ± 0.024^a	0.640 ± 0.027	0.439 ± 0.047^a
BFR/BS (um³/um²/day)	0.031 ± 0.003	0.007 ± 0.001^a	0.046 ± 0.006	0.017 ± 0.003^a

n=6

p≤.05

%BV/TV, Bone Volume/Total Volume; Tb. Th, Trabecular Thickness; Nob/BPm, number osteoblasts/bone perimeter; Noc/BPm, number osteoclasts/bone perimeter; ES/BS, eroded surface/bone surface; MS/BS, mineral surface/bone surface; MAR, mineral apposition rate; BFR/BS, bone formation rate/bone surface