Table 2. Description of all SNPs by chromosome and position with meta-analysis P-values less than 1.0×10-5.
| Population | RS number | Chr | Position | Variant* | MAF | P-value | HR (GWAS CI) | Closest Gene |
|---|---|---|---|---|---|---|---|---|
| EA | rs12638540 | 3 | 32463538 | A/G | 0.043 | 3.21 ×10-7 | 1.53 (1.01-2.31) | CMTM7 (intron) |
| EA | rs4528684 | 19 | 14212574 | C/T | 0.094 | 1.13 ×10-6 | 1.42 (0.99 – 2.03) | 34.6 kb from LPHN1 |
| EA | rs2125623 | 15 | 29616999 | C/T | 0.285 | 1.37 ×10-6 | 0.81 (0.65 – 1.01) | OTUD7A (intron) |
| EA | rs7965445 | 12 | 130428856 | G/A | 0.098 | 1.68 ×10-6 | 1.30 (0.99 – 1.72) | 11.9 kb from LOC338797 |
| EA | rs12422521 | 12 | 130426315 | T/C | 0.099 | 1.78 ×10-6 | 1.30 (0.99 – 1.72) | 9.4 kb from LOC338797 |
| EA | rs12422973 | 12 | 130430537 | G/C | 0.097 | 1.80 ×10-6 | 1.30 (0.99 – 1.72) | 13.6 kb from LOC338797 |
| EA | rs7299374 | 12 | 130428360 | G/T | 0.099 | 1.86 ×10-6 | 1.30 (0.99 – 1.72) | 11.4 kb from LOC338797 |
| EA | rs7977251 | 12 | 130436978 | C/T | 0.095 | 2.22 ×10-6 | 1.30 (0.98 – 1.73) | 20.0 kb from LOC338797 |
| EA | rs7976504 | 12 | 130437027 | G/A | 0.095 | 2.38 ×10-6 | 1.31 (0.98 – 1.73) | 20.1 kb from LOC338797 |
| EA | rs6486658 | 12 | 130432243 | C/T | 0.097 | 2.94 ×10-6 | 1.29 (0.98 – 1.70) | 15.3 kb from LOC338797 |
| EA | rs7687921 | 4 | 177096020 | A/T | 0.039 | 3.74 ×10-6 | 1.77 (0.95 – 3.28)** | GPM6A (intron) |
| EA | rs7120489 | 11 | 12425973 | G/A | 0.069 | 6.94 ×10-6 | 1.35 (0.96 – 1.90) | PARVA (intron) |
| EA | rs4979906 | 10 | 79114759 | A/G | 0.186 | 7.13 ×10-6 | 1.23 (0.98 – 1.55) | 46.6 kb from KCNMA1 |
| EA | rs17159640 | 7 | 111873569 | A/T | 0.048 | 8.52 ×10-6 | 1.59 (0.94 – 2.68) | IFRD1 (intron) |
| EA | rs9885413 | 5 | 110204027 | G/T | 0.065 | 9.76 ×10-6 | 1.34 (0.96 – 1.87) | 77.6 kb from SLC25A46 |
| AA | rs6868223 | 5 | 33672351 | G/A | 0.338 | 1.78 ×10-6 | 1.58 (0.98 – 2.56) | ADAMTS12 (intron) |
| AA | rs12733856 | 1 | 219618162 | C/A | 0.382 | 2.86 ×10-6 | 1.56 (0.97 – 2.51) | 42.0 kb from LOC400804 |
| AA | rs8017423 | 14 | 89749663 | T/C | 0.376 | 7.02 ×10-6 | 0.61 (0.36 – 1.06) | 27.7 kb from KCNK13 |
| AA | rs769044 | 14 | 89740891 | A/G | 0.372 | 9.52 ×10-6 | 0.62 (0.36 – 1.07) | 18.9 kb from KCNK13 |
| AA | rs6573013 | 14 | 54805626 | G/T | 0.141 | 9.64 ×10-6 | 1.74 (0.93 – 3.26) | 2.2 kb from FBXO34 |
EA = European ancestry; AA = African ancestry; Chr = chromosome; MAF = estimated minor allele frequency; HR = hazard ratio for the minor allele from the additive genetic model; GWAS CI = confidence interval for 5.0×10-7;
*
major/minor allele;
**
Only in CHS, RS and FHS