Table 2.

The Relation of cSHMT 1420C→T and Breast Cancer Risk in the Nurses’ Health Study.

	Odds Ratio (95% Confidence Interval)*	Odds Ratio (95% Confidence Interval)*
	Unadjusted Models	Adjusted Models†
1. cSHMT alone
cSHMT (referent genotype: CC)
CT	1.06 (0.88 – 1.28)	1.13 (0.88 – 1.45)
TT	0.98 (0.72 – 1.34)	1.13 (0.75 – 1.72)
P for trend:	0.81	0.36
2. cSHMT adjusted for MTHFR
cSHMT (referent: CC)
CT	1.05 (0.87 – 1.27)	1.09 (0.84 – 1.40)
TT	0.98 (0.72 – 1.33)	1.14 (0.75 – 1.75)
P for trend:	0.88	0.43
3. cSHMT adjusted for MTHFR, & Plasma Folate Quintiles
cSHMT (referent: CC)
CT	1.04 (0.82 – 1.32)	1.05 (0.77 – 1.43)
TT	0.94 (0.63 – 1.39)	0.91 (0.54 – 1.52)
P for trend:	0.92	0.91

^*Odds ratio and 95% confidence intervals are calculated from conditional logistic regression model coefficients and standard errors

^†Adjusted multivariate conditional logistic regression model accounted for matching factors and adjusted for height, BMI, calorie intake, alcohol intake (≥15 g/day or <15 g/day), age at menarche, age at first birth, parity, age at menopause, post-menopausal hormone use (current user or not current user), family history of breast cancer in a first degree relative (yes or no), and history of benign breast disease (yes or no).