Table 2.
Odds Ratio (95% Confidence Interval)* |
Odds Ratio (95% Confidence Interval)* |
|
---|---|---|
Unadjusted Models | Adjusted Models† | |
1. cSHMT alone | ||
cSHMT (referent genotype: CC) | ||
CT | 1.06 (0.88 – 1.28) | 1.13 (0.88 – 1.45) |
TT | 0.98 (0.72 – 1.34) | 1.13 (0.75 – 1.72) |
P for trend: | 0.81 | 0.36 |
2. cSHMT adjusted for MTHFR | ||
cSHMT (referent: CC) | ||
CT | 1.05 (0.87 – 1.27) | 1.09 (0.84 – 1.40) |
TT | 0.98 (0.72 – 1.33) | 1.14 (0.75 – 1.75) |
P for trend: | 0.88 | 0.43 |
3. cSHMT adjusted for MTHFR, &
Plasma Folate Quintiles |
||
cSHMT (referent: CC) | ||
CT | 1.04 (0.82 – 1.32) | 1.05 (0.77 – 1.43) |
TT | 0.94 (0.63 – 1.39) | 0.91 (0.54 – 1.52) |
P for trend: | 0.92 | 0.91 |
Odds ratio and 95% confidence intervals are calculated from conditional logistic regression model coefficients and standard errors
Adjusted multivariate conditional logistic regression model accounted for matching factors and adjusted for height, BMI, calorie intake, alcohol intake (≥15 g/day or <15 g/day), age at menarche, age at first birth, parity, age at menopause, post-menopausal hormone use (current user or not current user), family history of breast cancer in a first degree relative (yes or no), and history of benign breast disease (yes or no).