Table 1.
List of M. tuberculosis H37Rv and M. tuberculosis H37Ra proteins, with difference in relative abundance of 5 fold or higher.
| Protein IDs | Protein description | Gene Name | Functional group | Ratio H37Rv/H37Ra | Ratio H37Ra/H37Rv | TM number | References |
|---|---|---|---|---|---|---|---|
| Rv0319 | Probable conserved integral membrane protein | - | 3 | - | 6 b | 8 c | |
| Rv1101c | Conserved membrane protein | - | 3 | - | 5 | 8 | [21,60] |
| Rv1030 | Probable potassium-transporting p-type | - | 3 | - | 12 | 7 | |
| Rv2560 | Probable proline and glycine rich transmembrane | - | 3 | - | 24 | 4 | [21] |
| Rv2732c | Probable conserved transmembrane protein | - | 3 | - | 7 | 4 | |
| Rv0014c | Transmembrane serine/threonine-protein kinase b | - | 9 | - | 18 | 1 | [21] |
| Rv3584 | Possible conserved lipoprotein | lpqe | 3 | - | 11 | 1 | [21,60-63] |
| Rv3869 | Possible conserved membrane protein | - | 3 | - | 6 | 1 | |
| Rv0070c | Probable serine hydroxymethyltransferase | glya2 | 7 | - | 82 | 0 | [64] |
| Rv3576 | Possible conserved lipoprotein | lpph | 3 | - | 11 | 0 | [21] |
| Rv0402c | Probable conserved transmembrane transport | - | 3 | 7a | - | 12 | [61,64] |
| Rv0933 | Phosphate-transport ATP-binding ABC transporter | pstB | 3 | 106 | - | 0 | |
| Rv3273 | Probable transmembrane carbonic anhydrase | - | 7 | 33 | - | 10 | [60,62,63] |
| Rv2051c | Polyprenol-monophosphomannose synthase | ppm1 | 3 | 22 | - | 7 | [63,64] |
| Rv2877c | Probable conserved integral membrane protein | - | 3 | 5 | - | 7 | |
| Rv1273c | Probable drugs-transport transmembrane | - | 3 | 7 | - | 6 | |
| Rv1819c | Probable drugs-transport transmembrane | - | 3 | 6 | - | 6 | [60,63,64] |
| Rv2586c | Probable protein-export membrane protein | secf | 3 | 7 | - | 6 | [21,60,63] |
| Rv1779c | Hypothetical integral membrane protein | - | 3 | 21 | - | 4 | [64] |
| Rv2197c | Probable conserved transmembrane protein | - | 3 | 8 | - | 4 | [21,63] |
| Rv2617c | Probable transmembrane protein | - | 3 | 11 | - | 3 | |
| Rv0284 | Possible conserved membrane protein | - | 3 | 11 | - | 1 | [60,63,64] |
| Rv0291 | Probable membrane-anchored mycosin | mycp3 | 7 | 6 | - | 1 | [60-63] |
| Rv1209 | Conserved hypothetical protein | - | 10 | 19 | - | 1 | [21,63] |
| Rv1885c | Conserved hypothetical protein | - | 10 | 7 | - | 1 | [21] |
| Rv2289 | Probable cdp-diacylglycerol pyrophosphatase | cdh | 1 | 42 | - | 1 | [21,60,63] |
| Rv0265c | Probable periplasmic iron-transport lipoprotein | - | 3 | 7 | - | 0 | [21,61-63] |
| Rv0583c | Probable conserved lipoprotein lpqn | lpqn | 3 | 19 | - | 0 | [21,60,61,63] |
| Rv2833c | Probable sn-glycerol-3-phosphate-binding | - | 3 | 9 | - | 0 | [21,64] |
a Proteins more abundant in M. tuberculosis H37Rv strain compared to H37Ra strain. Relative abundance ratio calculated based on intensity measurements performed using MSQuant algorithm http://msquant.sourceforge.net/.
b Proteins more abundant in M. tuberculosis H37Ra strain compared to H37Rv strain. Relative abundance ratio calculated based on intensity measurements performed using MSQuant algorithm http://msquant.sourceforge.net/.
c Number of transmembrane regions predicted in the primary amino acid sequence by TMHMM v 2.0 http://www.cbs.dtu.dk/services/TMHMM/.