Table 1.
Biomarkers score
| Disease | Biomarkers (score) |
|---|---|
| Alzheimer's Disease | APLP2 (4), NEU2 (1.4), PCDH11X (0.5), SUMF1 (0.5), TOMM40 (0.5) |
| Amyotrophic Lateral Sclerosis | ALS2CR8 (0.5), DERL1 (0.5), FUS (1), HOPX (0.5), KIF1A (0.5), MOBKL2B (0.5), NIF3L1 (0.5), SCN7A (0.5), SEMA6A (1.4), SLC39A11 (0.5), STRADB (0.5), SUSD1 (0.5), UNC13A (0.5), ZFP64 (0.5) |
| Angelman Syndrome | ARID4A (1.4), ARID4B (0.5), MKRN3 (1), NDNL2 (0.5), NIPA2 (0.5), PHLDA2 (0.5), SLC9A6 (0.5), TSPAN32 (0.5), TSSC4 (0.5) |
| Asperger Syndrome | GPR172B (0.5) |
| Ataxia Telangiectasia | DDX10 (1), HEPACAM (1.4), TCL1A (0.5) |
| Canavan Disease | ASPA (0.5) |
| Dyslexia | ARFGEF1 (0.5), CCPG1 (0.5), PDGFC (0.5) |
| Epilepsy | TRAPPC10 (0.5) |
| Fatal Familial Insomnia | CD68 (0.5) |
| Friedreich Ataxia | ACO1 (0.5) |
| Huntington disease | AKAP8L (0.5), ARFIP2 (0.5) |
| Korsakoff Syndrome | TKTL1 (0.5) |
| Lambert-Eaton Myasthenic Syndrome | RAPSN (0.5), SOX1 (0.5) |
| Major Depressive Disorder | FKBP5 (1), PCLO (2) |
| Manic Depressive Psychosis | TRPM2 (0.5) |
| Multiple Sclerosis | CSMD1 (0.5), FCGR1A (2), FCGR1B (2), FCGR2A (3.5), FCGR2B (5), FCGR2C (4.1), FCGR3A (4.1), FCGR3B (0.5), IFNB1 (0.5) |
| Multiple System Atropy | AGTPBP1 (0.5), EXTL3 (0.5) |
| Parkinson's Disease | CALB1(5), CSF1R (5), MT-CYB (0.5), CHAC1 (0.5), NPFF (0.5) |
| Pathologic gambling | DNER (3.5) |
| Restless Legs Syndrome | DMRT1 (0.5) |
| Schizophrenia | AP3B2 (2), HMBS (0.5), SETD2 (1.4), ST6GAL2 (3.5) |
| Septo-Optic Dysplasia | LBX1 (1) |
| Stroke | NINJ2 (0.5), PROZ (0.5) |
| von Hippel-Lindau Disease | TCHP (0.5) |
The biomarkers of 24 diseases were indicated along with their diagnostic score. The biomarkers that are shown to be specific to neurological and psychiatric diseases in comparison with GWAS database are indicated in bold.