Table 5.

Univariate and multivariate analysis of prognostic factors for overall survival

Overall survival	Univariate Analysis		Multivariate Analysis
	HR (95% CI)	p value	HR (95% CI)	p value
Age (≤ 65 vs >65)	1.31 (0.93-1.87)	0.12
Sex (male vs female)	1.37 (0.99-1.91)	0.06
Primary Tumor	NA	0.01	NA	0.017
Site	NA	0.60
(subtentorial vs supratentorial)	0.72 (0.40-1.29)	0.28
(supratentorial and subtentorial vs supratentorial )	1.40 (0.96-2.05)	0.75
(supratentorial and subtentorial vs subtentorial	1.93 (1.1-2.53)	0.03
Neurologic Symptom (yes vs no)	1.51 (1.06-2.14)	0.02	0.66 (0.44-0.99)	0.046
RPA-RTOG classes	NA	0.21
(2 vs 1)	1.18 (0.77-1.70)	0.43
(3 vs 1)	1.78 (0.93-3.43)	0.08
(2 vs 3)	0.66 (0.36-1.19)	0.16
Type of treatment	NA	< 0.0001		0.02
(CT vs WBRT)	1.05 (0.72-1.53)	0.78	1.16 (0.76-1.76)	0.47
(Surgery/SRS vs WBRT)	0.37 (0.23-0.61)	< 0.0001	0.47 (0.26-0.87)	0.02
(Surgery/SRS vs CT)	0.35 (0.21-0.60)	< 0.0001	0.41 (0.21-0.77)	0.006
Number of brain metastases	NA	< 0.0001		0.013
(2-3 vs 1)	1.39 (0.86-2.24)	0.17	1.36 (0.79-2.34)	0.25
(>3 vs 1)	2.20 (1.48-3.27)	< 0.0001	2.04 (1.26-3.33)	0.004
(2-3 vs >3)	0.63 (0.41-0.96)	0.03	0.66 (0.41-1.07)	0.10