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Courses of infection in the control chimpanzee (Ctrl) (A) and in immunized chimpanzees Vac1 (B) and Vac2 (C). All animals were challenged at week 49 after immunization (arrow). PCR results with plasma for HCV RNA are indicated above each graph (−, negative; +, positive). Quantitative HCV RNA concentrations are shown as shaded areas (right y axis). The levels of the liver enzymes ALT and γ-GT are also plotted (black diamonds and black squares, respectively; left y axis).
