TABLE 1.
Heterogeneity of the amino acid sequences between vaccine DNA plasmids or recombinant proteins and the inoculum J4 sequences
| Sequences compared | Heterogeneity with indicated inoculum J4 sequencea
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Core (191 aa)b
|
E1 (192 aa)
|
E2 (363 aa)
|
NS3 (631 aa)
|
|||||
| % | No. of heterologous aa/total no. | % | No. of heterologous aa/total no. | % | No. of heterologous aa/total no. | % | No. of heterologous aa/total no. | |
| DNA vector products | 2.1 | 4/191 | 2.6 | 5/194c | 12.6 | 42/334d | 9.4 | 59/630 |
| Proteins | 2.1 | 4/191 | 5.9 | 8/135 | 13.5 | 41/304 | 4.7 | 14/299 |
a
Results are percentages of heterogeneity relative to the inoculum sequence
b
Numbers in parentheses indicate the total length of the protein sequence, and numbers of heterologous amino acids out of the total number used in the vaccines.
c
DNA plasmid also codes for part of the C terminus of core as a signal sequence for E1.
d
DNA plasmid also codes for part of the C terminus of E1 as a signal sequence for E2.