Figure 4. Frequency of descriptors for antagonists and agonists.

The most significant ligand descriptors are sorted according to their frequency of occurrence in the results of our approach. Most of them are found for both types of ligands (coloured), agonistic and antagonistic, but few of them (white) are specifically observed only for one of each ligand-type. Interestingly, despite occurrence of descriptors for both ligand types to an equal amount (gray), few shared descriptors are found in high or low amount for agonists or antagonists (cyan, yellow), respectively.