Table 2.
Odds ratios and attributable proportions due to interaction for different doses of smoking and SE alleles, regarding the risk to develop ACPA positive RA.
| No SE | Heterozygotic SE (SSE) |
Homozygotic SE (DSE) |
||||
|---|---|---|---|---|---|---|
| Smoking dose | No. ca/co* |
OR (95 % CI) ‡ | No. ca/co* | OR (95 % CI) ‡ | No. ca/co* | OR (95 % CI) ‡ |
|
| ||||||
| No Smoke | 38/154 | 1.0 (REF) § | 107/150 | 3.2 (2.0 - 4.9) | 62/43 | 6.3 (3.7 - 10.9) |
|
| ||||||
| 0 - 9 pack years | 25/104 | 1.0 (0.6 - 1.8) | 80/96 | 3.4 (2.1 - 5.6) | 54/19 | 12.0 (6.2 - 23.0) |
| AP** |
…
…
…
… |
… … … … | ……….. | 0.09 (−0.32-0.49) | … … … … | 0.47 (0.12 - 0.83) |
|
| ||||||
| 10 - 19 pack-years | 18/68 | 1.2 (0.6 - 2.2) | 83/56 | 7.3 (4.3 - 12.4) | 43/10 | 24.6 (10.9 - 55.8) |
| AP** |
…
…
…
… |
… … … … | ……….. | 0.53 (0.30 - 0.76) | … … … … | 0.73 (0.50 - 0.95) |
|
| ||||||
| 20- pack years | 30/87 | 1.9 (1.1 - 3.5) | 112/71 | 8.7 (5.3 - 14.4) | 83/13 | 37.6 (18.3 - 77.4) |
| AP** |
…
…
…
… |
… … … … | ……….. | 0.51 (0.31 - 0.72) | … … … … | 0.80 (0.67 - 0.94) |
|
| ||||||
| p-value for trend | p = 0.11 | p < 0.0001 | p < 0.0001 | |||
*
Number of exposed (exp) cases (ca) and controls (co),
**
Attributable proportion due to interaction (AP),
‡
Odds ratio (OR) and corresponding 95 percent confidence interval (95% CI) adjusted for sex, age and residential area,
§
Reference category.