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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Gastroenterology. 2010 Oct 16;140(3):966–975.e4. doi: 10.1053/j.gastro.2010.10.013

Figure 6. Depletion of CD11b+ Cells by Liposomal Cytotoxicity or Splenectomy Eliminates Therapeutic Effect of MSCs.

Figure 6

(A) Kaplan-Meier analysis of TNBS-induced mice depleted of monocytes and macrophages by liposomal clodronate and intravenously treated with saline or MSCs. (B) Total number of CD25+ Foxp3+ cells in mesenteric lymph nodes after treatment of monocytic-depleted mice. (C) Kaplan-Meier analysis of TNBS-induced mice intravenously treated with saline or MSCs that were splenectomized prior to disease induction. (D) Total number of CD25+ Foxp3+ cells in mesenteric lymph nodes after treatment of splenectomized mice. TNBS, trinitrobenzylsulfonic acid; MSC, bone marrow stromal cell.