Table 2.
Circulating levels of adipokines and other inflammatory markers in women with HPV persistent infection and HPV-uninfected women.
| HPV DNA Negative (n = 50) | HPV Persistent (n = 50) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Analytes | Mean | Median | SD | 95% CI | Mean | Median | SD | 95% CI | Fold Changea | p-valueb |
| Adiponectin (μg/ml) | 21.0 | 20.0 | 11.0 | 17.8–24.1 | 23.6 | 20.9 | 10.0 | 20.6–26.5 | 1.0 | 0.074 |
| Resistin (ng/ml) | 32.6 | 24.6 | 25.3 | 25.4–39.8 | 147.8 | 89.2 | 356.8 | 46.4–249.2 | 3.6 | <0.0001 |
| Leptin (ng/ml) | 26.5 | 21.1 | 19.7 | 21.0–32.1 | 37.6 | 27.5 | 39.9 | 26.3–49.0 | 1.3 | 0.29 |
| sVCAM-1 (ng/ml) | 545.1 | 463.5 | 275.3 | 466.8–623.3 | 608.1 | 569.2 | 259.0 | 534.5–681.7 | 1.2 | 0.058 |
| sICAM-1 (ng/ml) | 206.1 | 196.7 | 63.1 | 188.1–224.0 | 223.6 | 205.8 | 80.1 | 200.9–246.4 | 1.0 | 0.25 |
| sFas (ng/ml) | 6.9 | 6.4 | 1.9 | 6.3–7.4 | 9.3 | 7.2 | 11.5 | 6.0–12.6 | 1.1 | 0.0038 |
| CRP (ng/ml) | 4170.0 | 3363.0 | 3886.0 | 3066–5274 | 5033.0 | 2549.0 | 8709.0 | 2558–7508 | 0.8 | 0.92 |
| IL-8 (pg/ml) | 121.0 | 9.8 | 235.0 | 54.1–187.4 | 517.0 | 324.2 | 544.0 | 362.0–671.0 | 33.1 | <0.0001 |
| TNF-α (pg/ml) | 28.0 | 4.8 | 63.0 | 9.7–46.0 | 88.0 | 62.0 | 77.0 | 66.0–109.0 | 12.8 | <0.0001 |
a
Fold change was calculated based on the median values of cases compared to controls
b
Calculated using Mann-Whitney test
Abbreviations: SD, Standard Deviation; CI, Confidence Interval