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. 2010 Dec 14;30(3):546–555. doi: 10.1038/emboj.2010.330

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Copyright © 2011, European Molecular Biology Organization

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

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G6PD activity in human cells. (A) AG02603 cells were treated with or without 10 μM ATMi or 5 mM caffeine before being exposed to 10 Gy of IR. Cells were then lysed and G6PD activity was determined over the time as indicated. (B) Normal fibroblasts (GM0024B), A-T fibroblasts (GM03395), normal lymphoblasts (GM0558) and A-T lymphoblasts (GM03382) were irradiated with 10 Gy or left untreated. These cells were then lysed and G6PD activity was determined on whole cell extracts. The histogram represents the average fold increase of G6PD activity over non-treated corresponding cells. Error bars indicate s.d.