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The TRPV1 lineage predominates embryonically, yet channel expression is refined over development. However, upon embryonic ablation of neurons within this lineage, animals become unresponsive to thermal stimuli, both heat and cold, due to an apparent loss of all thermoreceptors. Nonetheless, mechanosensation remains intact, indicating that molecules and receptors involved in this modality are not within the TRPV1 lineage.
