TABLE 4.
Map of epitopes revealed by grouping amino acid changes recognized by individual antibodies in H9 escape mutantsa
| Epitope | MAb | Amino acid change(s) preventing HA-MAb interaction
|
||
|---|---|---|---|---|
| Site I | Overlapping area | Site II | ||
| I | 15F1 | P162L | T198N | |
| G9-27 | P162L, K157T, T135K | S133N | ||
| G9-6 | P162L, K157T, T135K | S133N | ||
| G1-26 | P162L, K157T, T135K | S133N | ||
| G1-29 | K157T, T135K | T189A, S133N | N193T | |
| G9-25 | K157T, T135K | S133N | ||
| 18G4 | T135K | S133N | ||
| II | 19A10 | L226Q, D145E | ||
| 18B1 | L226Q, N193D, D145E N193T | |||
| 2F4 | L226Q, N193D, D145E | |||
| 4G3 | S133N | L226Q, N193D, D145E N193T | ||
| 7B10 | L226Q, N193D, D145E N193T | |||
| 3D11 | S133N | L226Q, N193D N193T | ||
| 8C4 | T198N | N193D N193T | ||
| 18B10 | T198N, T189A | N193T | ||
a
Positions of amino acid substitutions are numbered according to H3 subtype of HA.