Table 1.

Inhibitory effect of statin to chondrocyte life-span

Group	In vitro life-span (remaining replicative capacity) Populating doubling
Control	18,5 ± 3,4
IL-β	12,6 ± 3,6 a
Simvastatin 1Mμ	19,4 ± 3,3
Simvastatin 10 Mμ	16,8 ± 5,0
IL-1 (10 ng/ml) + Simvastatin 1Mμ	20.3 ± 4.2 b
IL-1 (10 ng/ml) + Simvastatin 1Mμ	17.8 ± 3,0 c

^ap < 0.01, compared to control

^{b and c}p < 0.01 compared to IL-1β-stimulated group