TABLE 1.

Nucleotide and amino acid mutations found in 293Rep replicons relative to the Con1 replicon sequence

Protein	Mutation		Presence of mutation in replicona
	nt	aa	S22.3p98	293Rep5	S22.3p79	293Rep17
NS2	G2784A	A815T	X	X
	T3004C	I888T	X	X	X	X
	T3134G		X
NS3	C3459T	L1040F		X
	C3535T	A1065V				X
	T3650C					X
	T3881C			X
	C4028T			X
	C4043T		X	X	X	X
	A4143G	M1268V		X
	A4154G			X
	C4172T					X
	T4394G			X
	T4592C			X
	C4685T				X	X
	A5019G	S1560G	X	X	X	X
NS4A	C5442T	L1701F				X
NS4B	T5489C					X
	A5646G	I1769V	X	X
	T5681C			X
	A5730G	I1797V			X	X
	C5774T					X
NS5A	A6334G	K1998R		X
	G6465C	G2042R	X	X	X	X
	G6618A	V2093I	X	X
	T6805C	L2155P		X
	G6956A					X
	A7075G	E2245G				X
	T7106C				X	X
	C7314T	P2325S			X	X
	T7347C	S2336P	X	X
	A7349G		X	X	X	X
	G7368A	A2343T		X
	T7513C	L2391P		X
	T7554A	W2405R				X
	T7557C	S2406P		X
	A7565G					X
NS5B	A7653C	T2438P				X
	A7733G			X
	C7767T			X
	A8348G					X
	G8441A				X	X
	T8447C					X
	C8603T			X
	C8860T	A2840V			X	X
	T8999C		X	X	X	X
	A9131G		X	X
	T9225G	S2962V		X
	C9226T	S2962V
	C9368Y					X

^aX, mutation is present.