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. Author manuscript; available in PMC: 2011 Dec 22.
Published in final edited form as: Neuron. 2010 Dec 22;68(6):1082–1096. doi: 10.1016/j.neuron.2010.11.026

Figure 1.

Figure 1

AMPA receptors co-expressed with γ-4, γ-7 or γ-8 show resensitization. (A) Representative trace of glutamate-evoked current in a HEK293T cell co-transfected with GluA1 and γ-8. Glutamate-evoked current rapidly desensitizes and then gradually resensitizes (IGlu−Resens), until reaching steady-state (IGlu−SS). Resensitization time course fits to a single exponential curve (red line). (B) TARPs γ-4, γ-7 and γ-8, but not γ-2, γ-3 or γ-5 impart resensitization to GluA1. (C) Glutamate-evoked currents with GluA1-4 subunit homomers and GluA1/2 heteromers co-expressed with γ-8 show resensitization. Philanthotoxin was added to isolate the currents mediated by GluA1 + GluA2-flop + γ-8 from those by GluA1 + γ-8. Note that the time constants for resensitization (τ) depend upon GluA subunits and TARPs. (D) γ-4, -7 and -8 exhibit resensitization. (E) Resensitization does not depend on the size of the elicited steady state current. Numbers of repetitions are indicated above the bar graphs. Summary data are mean ± S.E.M. See also Figure S1.