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. Author manuscript; available in PMC: 2011 Dec 22.
Published in final edited form as: Neuron. 2010 Dec 22;68(6):1082–1096. doi: 10.1016/j.neuron.2010.11.026

Figure 2.

Figure 2

Blocking desensitization occludes γ-8-mediated resensitization. (A) Representative traces of glutamate-evoked currents from GluA1 and GluA1 + γ-8 in the presence of CTZ, which blocks desensitization. (B) Typical traces of glutamate-evoked currents from the non-desensitizing mutant GluA1L497Y with or without γ-8. Resensitization percentage is IGlu−Resens/IGlu−max. (C) CTZ or the L497Y mutation abolishes resensitization even in the presence of γ-8. (D) The ratio of kainate / glutamate-evoked currents confirms γ-8 incorporation. (E, F) Steady state current levels elicited by glutamate (E) and kainate (F). Summary data are mean ± S.E.M. See also Figure S2.