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. Author manuscript; available in PMC: 2011 Dec 22.
Published in final edited form as: Neuron. 2010 Dec 22;68(6):1082–1096. doi: 10.1016/j.neuron.2010.11.026

Figure 8.

Figure 8

Recapitulation of hippocampal AMPA receptors pharmacology requires both CNIH-2 and γ-8. (A) Representative traces of kainate-evoked responses in the presence or absence of CTZ from (A1–5) recombinant cells, (A6) acutely isolated hippocampal (Hp) neurons, or (A7–8) cultured hippocampal neurons. (B) Quantification of CTZ potentiation of kainate-evoked responses. * denotes p<0.05 when compared to GluA1o/2 and # denotes p<0.05 when compared to untransfected cultured hippocampal neurons. The dotted line represents the mean CTZ-induced IKA potentiation observed in acutely isolated or cultured hippocampal neurons. Note that a 50% reduction in the amount of CNIH-2 transfected relative to GluA subunit reduces CTZ potentiation of kainate-evoked currents, which is qualitatively similar to the effect of CNIH-2 shRNA transfection in cultured hippocampal neurons. Summary data are mean ± S.E.M. See also Figure S7.