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Moderate calorie restriction promotes an increased stress state. A, Restraint stress-induced HPA axis corticosterone response was significantly elevated in calorically restricted (Rstr) mice (ad libitum, n = 11; Rstr, n = 12) (*p < 0.05). B, Maladaptive behavioral responses were detected in a tail suspension test in which restricted mice showed a significant increase in time spent immobile compared with ad libitum (ad libitum) fed mice (n = 11–12). Data are mean ± SEM.
