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. Author manuscript; available in PMC: 2011 Feb 7.
Published in final edited form as: J Neuropathol Exp Neurol. 2007 Dec;66(12):1136–1146. doi: 10.1097/nen.0b013e31815c5efb

FIGURE 1.

FIGURE 1

Histopathologic hallmarks of Alzheimer disease (AD). A neurofibrillary tangle (diagonal arrows) and neuritic plaque (oval-shaped structure on right) are shown in a photomicrograph from human AD brain section stained with the silver-impregnation Bielschowsky technique. Neurofibrillary tangles are composed of insoluble and protease-resistant fibrils, and develop intracellularly. Neuritic plaques are extracellular fibrillary amyloid deposits, surrounded by swollen, degenerating, silver-impregnated neurites. Scale bar = 50 μm.