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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Pulm Pharmacol Ther. 2010 Sep 17;24(1):92–99. doi: 10.1016/j.pupt.2010.09.004

Table 1.

Examples of Therapeutic Strategies for Mitigating SM-induced Lung Injury

Target Therapeutics References
Inflammation Anti-inflammatory agents (macrolide antibiotics, glucocorticoids) 33, 48, 64, 65, 72, 78, 80, 83, 84
Oxidative stress Antioxidants (tocopherols, NAC, catalase, SOD, catalytic metalloporphyrins, melatonin) 28, 40, 54, 57, 60, 65, 71, 77, 85, 86, 87, 89, 90, 91, 93
Proteases Protease inhibitors (doxycyline, ilomastat, aprotinin) 40, 51, 63
Pulmonary surfactants Surfactants (Curosurf) 47