Table 3.

Gene-gene Interaction between Metabolic Gene SNPs CYP1A1 c.1384A>G and EPHX1 c.337T>C Stratified by Smoking and Gender

	No. (%) of Patients	OR (95% CI)	P	OR (95% CI)*	P
Never-smoker
CYP1A1 c.1384A>G (AA as referent; n=363)
EPHX1 c.337T>C (TT as referent; n=216)
TC + AG/GG	20	1.29 (0.68–2.47)	0.43	1.14 (0.57 – 2.3)	0.7
CC + AG/GG	10	2.67 (1.16–6.15)	0.02	3.07 (1.2 – 7.81)	0.02
TC/CC + AG/GG	30	1.57 (0.87–2.82)	0.13	1.46 (0.78 – 2.77)	0.24
Ever-smoker
CYP1A1 c.1384A>G (AA as referent; n=336)
EPHX1 c.337T>C (TT as referent; n=164 )
TC + AG/GG	16	1.46 (0.66–3.26)	0.35	1.66 (0.72 – 3.83)	0.23
CC + AG/GG	8	3.59 (1.33–9.65)	0.01	3.33 (1.16 – 9.54)	0.02
TC/CC + AG/GG	24	1.82 (0.87–3.84)	0.11	1.99 (0.91 – 4.34)	0.08
Males
CYP1A1 c.1384A>G (AA as referent; n=415)
EPHX1 c.337T>C (TT as referent; n=221)
TC + AG/GG	24	2.13 (1.07 – 4.26)	0.03	2.21 (1.05 – 4.65)	0.04
CC + AG/GG	13	4.58 (2.0 – 10.44)	<0.001	4.53 (1.82 – 11.27)	0.001
TC/CC + AG/GG	37	2.63 (1.38 – 5.0)	0.003	2.7 (1.35 – 5.4)	0.005
Females
CYP1A1 c.1384A>G (AA as referent; n=284)
EPHX1 c.337T>C (TT as referent; n=159)
TC + AG/GG	12	0.72 (0.34 – 1.55)	0.41	0.75 (0.34 – 1.65)	0.47
CC + AG/GG	5	1.67 (0.57 – 4.94)	0.35	1.76 (0.56 – 5.56)	0.33
TC/CC + AG/GG	17	0.87 ( 0.43 – 1.74)	0.69	0.9 (0.43 – 1.85)	0.77

^*OR adjusted for age, gender and race (White vs. other) for analysis stratified by smoking and age, race and smoking for analysis by gender