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. Author manuscript; available in PMC: 2012 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Dec 4;21(2):730–733. doi: 10.1016/j.bmcl.2010.11.117

Table 1.

Shp2 PTP inhibitory activity of Estramustine phosphate analogs

Compound IC50 (µM)
Estramustine phosphate 17.10 ± 9.21
Estramustine >300
Estradiol phosphate 19.9 ± 10.3
Estradiol >300
NSC233064 >300
Enoxolone 9.6 ± 3.2
Celastrol 3.3 ± 0.6
Maitenin 61.6 ± 24.2