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. Author manuscript; available in PMC: 2012 Jan 25.
Published in final edited form as: Eur J Pharmacol. 2011 Jan 25;651(1-3):96–105. doi: 10.1016/j.ejphar.2010.10.085

Table 1.

Cannabinoid CB1 and CB2 Receptor Binding Affinities and Pharmacological Effects of Sulfonamides with Dimethyl and Acetylene Side Chain Substitutions*

graphic file with name nihms-256576-t0007.jpg
Ki (nM) ED50
ID
(MW)		 R CB1 CB2 SA TF RT
O-2050
(418)		 graphic file with name nihms-256576-t0008.jpg 2.5 ± 0.4 0.2 ± 0.1 69% @
30		 < 30 < 30
O-1991
(432)		 graphic file with name nihms-256576-t0009.jpg 30 ± 13 1.4 ± 0.2 2
(1-3)		 0.9
(0.6-1.4)		 0.8
(0.4-1.6)
O-1993
(460)		 graphic file with name nihms-256576-t0010.jpg 70 ± 10 86 ± 7 8
(3-16)		 14
(7-27)		 12
(9-15)
O-2113
(459)		 graphic file with name nihms-256576-t0011.jpg 1.7 ± 0.3 0.08 ± 0.02 0.4
(0.1-1.8)		 0.3
(0.1-1)		 1.4
(0.3-4.6)
JWH-104**
(354)		 graphic file with name nihms-256576-t0012.jpg 909 ± 121 137 ± 6 5
(3-10)		 2
(1-3)		 1
(0.7-2)
*

Kis are presented as means ± S.E.M. All ED50s are expressed as mg/kg (with 95% confidence limits in parentheses). For compounds that failed to produce either maximal or dose-related effects, the percent effect at the highest dose (mg/kg) or > highest dose tested (in cases where largest response was less than 50% of the typical maximum) is indicated. MW = molecular weight; SA = suppression of spontaneous activity; MPE = % maximum possible antinociceptive effect in tail flick assay; RT = rectal temperature.