Table 1.

Antiviral activity of 1 and its analogs against HIV-1 IIIB in MT-2 cells.

No.	R1	R2	R3	R4	R5	μM (± SD)
						IC50	CC50
1			H	H	CH3	4.02 ± 0.28	>67.13
2			H	H	CH3	4.23 ± 0.39	>64.7
3			H	H	CH3	7.25 ± 0.54	>64
4			H	H	CH3	>16.5	>66.1
5			H	H	CH3	2.67 ± 0.5	9.2 ±1.0
6			CH3	H	H	1.06 ± 0.05	>61.45
7			CH3	H	H	>16.7	ND
8			CH3	H	H	2.16 ± 0.07	>55.4
9			CH3	H	H	9.28 ± 0.68	>67.1
10		CF3	CH3	H	H	>27.5	ND
11			CH3	H	H	>24.5	ND
12			CH3	H	H	>25.6	ND
13			CH3	H	H	9.2 ± 0.7	70.7 ± 5.4
14			CH3	H	H	>23.6	ND
15			CH3	H	H	7.1 ± 0.4	>20.4
16			CH3	H	H	>25.2	ND
17			CH3	H	H	8.2 ± 1.2	>23.5
18			CH3	H	H	>21.9	ND
19			CH3	H	H	>24.8	ND
20			CH3	H	H	>24.1	ND
21			CH3	H	H	>23.6	ND
22			CH3	H	H	>26.6	ND
23			CH3	H	H	4.7 ± 0.6	>24.5
24			CH3	H	H	>22.1	ND
25			CH3	H	H	>38.9	ND
26			CH3	H	H	9.27 ± 0.3	44.5 ± 5.5
27			C2H5	H	H	>13.9	ND
28			C2H5	H	H	12.3 ± 0.85	>127.4
29			OCH3	H	H	>13	ND
30			OCH3	H	H	7.87 ± 1.0	>31
31			OCH3	H	H	>25.7	ND
32			CH3	H	H	11.7 ± 1.2	>63.4
33			CH3	H	H	11.8 ± 0.4	>64
34			CH3	H	H	>12.9	ND
35			CH3	H	H	5.0 ± 0.2	12.7 ± 1.0
36			CH3	H	CH3	8.6 ± 1.1	>96
37			OCH3	H	H	7.9 ± 0.4	25 ± 1.0
38			OCH3	H	H	6.1 ± 0.7	>48
39			H	CH3	H	>14.6	ND
40			H	CH3	H	>15	ND
41			H	CH3	H	>16.8	ND
42			H	CH3	H	12.4 ± 0.6	>51.2
43			H	CH3	H	>16.2	ND
44			H	H	CH3	3.59 ± 0.36	>60
45			CH3	H	H	3.09 ± 0.55	>67.13
46			CH3	H	H	6.51 ± 0.94	>65
47			CH3	H	H	6.4 ± 0.17	>19.8
48			CH3	H	H	5.8 ±0.36	>117

ND, Not determined