Skip to main content
. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Bioorg Med Chem. 2010 Nov 25;19(1):77–90. doi: 10.1016/j.bmc.2010.11.045

Table 2.

Antiviral activity of compound 49 and its analogs against HIV-1 IIIB in MT-2 cells.

graphic file with name nihms256229u2.jpg
New No. R μM (± SD)
IC50 CC50
49 graphic file with name nihms256229t96.jpg 33.5§ >134.41
50 graphic file with name nihms256229t97.jpg 6.69 ± 0.3 >128.08
51 graphic file with name nihms256229t98.jpg 6.8 ± 0.25 <7.6
52 graphic file with name nihms256229t99.jpg 33.23§ 42.10§
53 graphic file with name nihms256229t100.jpg 30.0§ >34.15†
54 graphic file with name nihms256229t101.jpg 6.9 ± 0.7 24.04§
55 graphic file with name nihms256229t102.jpg 1.78± 0.17 >37.50†
56 graphic file with name nihms256229t103.jpg >30.6† >30.60§
57 graphic file with name nihms256229t104.jpg >32† >63.7§
58 graphic file with name nihms256229t105.jpg >16.5† >66.1§
§

50% antiviral activity or toxicity at this dose

†

0–30% antiviral activity or toxicity at this dose