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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Arthritis Rheum. 2010 Jul;62(7):2117–2126. doi: 10.1002/art.27463

Figure 2. SSc fibroblasts show increased sensitivity to the anti-fibrotic effects of dhS1P.

Figure 2

Six pairs of SSc and closely matched control fibroblasts were stimulated with 0.5 μM of dhS1P for 48 hours. Left panel depicts the protein levels of PTEN, MMP-1, and collagen determined by western blotting in a representative pair. β-actin was used to normalize protein levels. Lines 1 and 2 represent NS fibroblasts, lanes 3 and 4, SSc fibroblasts. Right panel represents graphical summary of the experiment. Bar graph depicts mean±SD from all pairs tested expressed as a ratio of each protein level to β-actin level. *p<0.05, **p<0.01, ***p<0.001