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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Clin Pharmacol Ther. 2010 Nov 24;89(1):97–104. doi: 10.1038/clpt.2010.250

Figure 3.

Figure 3

Glycine synthesis and degradation. The figure shows a schematic representation of glycine synthesis and degradation. SHMTs are the two serine hydroxymethyltransferase isoforms that catalyze the synthesis of glycine from serine, a reaction coupled with the conversion of tetrahydrofolate (THF) to 5,10-methylene THF. AMT, aminomethyltransferase; DLD, dihydrolipoamide dehydrogenase; GCSH, glycine cleavage system protein H and GLDC, glycine dehydrogenase, are components of the multiple-enzyme glycine cleavage system, the major pathway for glycine degradation.