Table 2.
Association results with p-values <0.05 for citalopram/escitalopram treatment outcomes.
| (A) SNPs associated with “remission” after SSRI treatment outcome. | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Remission (last visit) |
Remission (week 8) |
||||||||
| rs# | chr | gene | location | MAF (non-remitters/remitters) | OR (95% CI) | p-value | MAF (non-remitters/remit) | OR (95% CI) | p-value |
| rs1658957 | 9 | GLDC | 5′-flanking | 0.47/0.54 | 1.3 (1.0,1.7) | 0.026 | 0.48/0.54 | 1.3 (0.97,1.7) | 0.084 |
| rs10975734 | 9 | GLDC | 5′-flanking | 0.26/0.33 | 1.4 (1.1,1.9) | 0.013 | 0.25/0.33 | 1.5 (1.1,2.1) | 0.007 |
| rs11789777 | 9 | GLDC | intron9 | 0.34/0.28 | 0.76 (0.58,0.99) | 0.043 | 0.33/0.28 | 0.77 (0.58,1.0) | 0.083 |
| rs10975641 | 9 | GLDC | intron17 | 0.43/0.34 | 0.70 (0.53,0.91) | 0.008 | 0.43/0.34 | 0.68 (0.51,0.91) | 0.009 |
| (B) SNPs associated with “response” and percentage change in QIDS-C after SSRI treatment outcome. | ||||||||
|---|---|---|---|---|---|---|---|---|
| Response |
Percent change in QIDS-C score |
|||||||
| rs# | chr | gene | location | MAF (non-responders/responders) | OR (95% CI) | p-value | Spearman correlation coefficient | p-value |
| rs11612037 | 12 | SHMT2 | 5′-flanking | 0.06/0.03 | 0.46 (0.23,0.92) | 0.029 | 0.072 | 0.147 |
| rs7485577 | 12 | SHMT2 | 5′-flanking | 0.26/0.33 | 1.4 (0.99,1.9) | 0.060 | −0.102 | 0.040 |
| rs2988418 | 9 | GLDC | intron2 | 0.23/0.17 | 0.68 (0.46,0.99) | 0.045 | 0.112 | 0.023 |
| rs1755615 | 9 | GLDC | intron2 | 0.28/0.22 | 0.71 (0.50,1.0) | 0.039 | 0.114 | 0.022 |
| rs12004478 | 9 | GLDC | intron15 | 0.37/.030 | 0.75 (0.55,1.0) | 0.045 | 0.116 | 0.019 |
| rs10975641 | 9 | GLDC | intron17 | 0.44/0.36 | 0.73 (0.54,0.99) | 0.043 | 0.136 | 0.006 |
(A) SNPs associated with “remission” after citalopram/escitalopram treatment. (B) SNPs associated with “response” and percentage change in QIDS-C after SSRI treatment. SNPs are listed based on their chromosomal locations. OR and p-values were adjusted for population stratification with 4 eigenvectors. The rs10975641 SNP that was subsequently validated for the “response” phenotype in the STAR*D study is “boxed”.