Figure 2.
Striatal Aβ (A, 20X) and tau pathology (B, 40X and D, 400X) in the case with an S212Y PSEN1 mutation. In comparison to a sporadic Alzheimer’s disease (AD) case (C, 400X, Braak stage VI), the tau pathology was substantially more severe. No difference was observed in the severity of Aβ deposition between the familial AD case and sporadic AD cases.