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. Author manuscript; available in PMC: 2011 Jul 11.
Published in final edited form as: Sci Signal. 2011 Jan 11;4(155):ra1. doi: 10.1126/scisignal.2001230

Fig. 4.

Fig. 4

The M3-R–selective antagonists darifenacin and pfHHSiD attenuate odor-mediated responses of OSNs. (A) Kinetics of changes in the ratio of Fluo-4 and Fura-red fluorescence for a representative OSN stimulated by a mixture of 10 odorants (10 μM each) with or without darifenacin. (B) Darifenacin (100 nM) attenuated odor-mediated responses of OSNs. (P values shown are from paired t tests; n = 36, 18, and 18 OSNs for each pair of treatments.) (C) Kinetics of changes in the ratio of Fluo-4 and Fura-red fluorescence for a representative OSN stimulated by a mixture of odorants with or without pfHHSiD. (D) pfHHSiD (1 μM) attenuated odor-mediated responses of OSNs. (P values shown are from paired t tests; n = 34, 15, and 19 OSNs for each pair of treatments.)