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. Author manuscript; available in PMC: 2011 Feb 7.
Published in final edited form as: J Am Chem Soc. 2008 Feb 15;130(10):2959–2961. doi: 10.1021/ja709993p

Figure 2.

Figure 2

CS-E glycopolymers inhibit the outgrowth of hippocampal neurons. (A) Immunofluorescence images of neurons 48 h after treatment with the indicated compound. A fixed glucuronic acid concentration of 0.5 μg/mL was used in each case to examine the effects of multivalency. The molar concentrations were 14.3 nM for the natural CS-E polysaccharide, 12.1 nM for the CS-E tetrasaccharide polymer, and 16.6–53.0 nM for the disaccharide polymers. See Supporting Information for details. (B) Statistical analysis of neurite length. Error bars represent SEM from three separate experiments. P values are relative to the untreated neurons. See Supporting Information for conditions.