Figure 1.
TLR4 deficiency reduced intimal lipid accumulation in the lesser curvature of the aortic arch (LCAA) of 36 week-old chow-fed male mice. Representative photographs depict en face analysis of oil Red O-stained ascending and descending aorta, from its origin to the iliac bifurcation. Mean and individual LCAA lesion areas in mm2 are shown in the chart. Bars indicate means; symbols indicate individual values. Minimal lipid accumulation was seen in the descending aorta. Number of mice per group: ApoE (12), TLR2 DKO (6), and TLR4 DKO (6). *P < 0.05 vs. ApoE KO.