Table 1.
Baseline Characteristics. Clinical characteristics of study subjects by Race and Albuminuric Status
| Stage 1 | Stage 2 | |||||||
|---|---|---|---|---|---|---|---|---|
| European Americans (n = 1803) | European Americans (n = 6319) | |||||||
| Characteristic | Control Subjects | Albuminuria Cases | Control Subjects | Albuminuria Cases | ||||
| N | 1646 | 157 | 5945 | 374 | ||||
| Age, mean(SD), y | 63.2 | (5.6) | 64.9 | (5.6)*** | 62.8 | (5.6) | 65.2 | (5.6)*** |
| Male, No. (%) | 802 | (48.7) | 92 | (58.6)* | 2655 | (44.7) | 199 | (53.2)** |
| Hypertension, No. (%) | 731 | (44.4) | 111 | (70.7)*** | 2266 | (38.1) | 269 | (71.9)*** |
| Type 2 Diabetes, No. (%) | 480 | (29.2) | 84 | (53.5)*** | 428 | (7.2) | 103 | (27.5)*** |
| Body mass index, kg/m2 | 29.0 | (5.5) | 30.0 | (6.3)* | 28.0 | (5.0) | 28.8 | (6.0)** |
| SBP (mmHg) | 126.8 | (17.4) | 135.7 | (20.4)*** | 124.4 | (17.8) | 138.3 | (23.2)*** |
| DBP (mmgHg) | 69.7 | (10.0) | 70.0 | (11.1) | 69.5 | (9.6) | 72.5 | (12.1)*** |
| Fasting Glucose (mg/dL)§ | 115.4 | (34.9) | 134.4 | (52.2)*** | 102.1 | (21.2) | 116.8 | (43.4)*** |
| GFR, ml/min per 1.73 m2 | 81.7 | (16.9) | 75.0 | (25.7)*** | 80.7 | (16.1) | 76.1 | (22.3)*** |
| ACR, μg/mg, median (25%ile, 75%ile) | 3.7 | (1.8,6.7) | 102.6 | (47.4,275.0)*** | 3.6 | (2.0,6.5) | 74.8 | (44.4,166.7)*** |
| African Americans (n = 1135) | African Americans (n = 1021) | |||||||
| Characteristic | Control Subjects | Albuminuria Cases | Control Subjects | Albuminuria Cases | ||||
| N | 987 | 148 | 875 | 146 | ||||
| Age, mean(SD), y | 61.3 | (5.5) | 63.0 | (5.8)††† | 61.8 | (5.7) | 62.5 | (5.7) |
| Male, No. (%) | 336 | (34.0) | 44 | (29.7) | 324 | (37.0) | 54 | (37.0) |
| Hypertension, No. (%) | 615 | (62.3) | 127 | (85.8)††† | 558 | (63.8) | 127 | (87.0) ††† |
| Type 2 Diabetes, No. (%) | 217 | (22.0) | 80 | (54.1)††† | 196 | (22.4) | 80 | (54.8) ††† |
| Body mass index, kg/m2 | 30.7 | (6.5) | 30.8 | (6.6) | 30.3 | (5.9) | 31.4 | (6.6) † |
| SBP (mmHg) | 131.2 | (18.4) | 144.4 | (23.2)††† | 132.0 | (18.9) | 144.8 | (22.5) ††† |
| DBP (mmgHg) | 75.0 | (10.0) | 78.2 | (13.0)††† | 75.7 | (10.1) | 78.5 | (11.9) †† |
| Fasting Glucose (mg/dL) § | 114.3 | (39.6) | 136.4 | (62.2)††† | 112.7 | (38.5) | 137.9 | (62.8) ††† |
| GFR, ml/min per 1.73 m2 | 91.5 | (19.0) | 83.0 | (29.8) ††† | 90.9 | (21.0) | 80.7 | (29.3) ††† |
| ACR, μg/mg, median (25%ile, 75%ile) | 1.9 | (0.7,4.7) | 95.9 | (47.2,363.2)††† | 2.2 | (0.8,5.2) | 81.7 | (44.7,249.7) ††† |
Data are means (SD), number (%), or for ACR median (25%ile, 75%ile). European Americans: * P < 0.05; **P < 0.01; ***P < 0.001.
African Americans: †P < 0.05; ††P < 0.01; †††P < 0.001.
§Individuals with fasting glucose measured. Evaluation set (European Americans n = 1582 controls and n = 150 cases; African Americans n = 922 controls and n = 113 cases). Valdiation set (European Americans n = 5822 controls and n = 356 cases; African Americans n = 787 controls and n = 113 cases).