Table 2.
Stage 1GLUT1 Enh2 and XbaI Risk genotype distributions among case and control subjects and odds ratio of albuminuria, by diabetes and race
| European Americans | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Type 2 Diabetes | No Type 2 Diabetes | |||||||||
| SNP | Controls | Cases | P-value | OR (95% CI) | Controls | Cases | P-value | OR (95% CI) | ||
| Enh2 SNP (C > T) | 480 | 84 | 1166 | 73 | ||||||
| CC or CT | (94.6) | (88.1) | 0.025 | 1.00 | (94.7) | (93.1) | 0.574 | 1.00 | ||
| TT | (5.4) | (11.9) | 2.36 | (1.09 - 5.09)* | (5.3) | (6.9) | 1.31 | (0.51 - 3.36) | ||
| XbaI SNP (C > A) † | 348 | 70 | 866 | 62 | ||||||
| CC or CA | (94.5) | (88.6) | 0.064 | 1.00 | (94.2) | (90.3) | 0.212 | 1.00 | ||
| AA | (5.5) | (11.4) | 2.23 | (0.94 - 5.33) | (5.8) | (9.7) | 1.75 | (0.72 - 4.25) | ||
| African Americans | ||||||||||
| Type 2 Diabetes | No Type 2 Diabetes | |||||||||
| SNP | Controls | Cases | P-value | OR (95% CI) | Controls | Cases | P-value | OR (95% CI) | ||
| Enh2 SNP (C > T) | 217 | 80 | 770 | 68 | ||||||
| CC or CT | (99.5) | (100.0) | 0.543 | 1.00 | (99.7) | (100.0) | 0.674 | 1.00 | ||
| TT | (0.5) | (0.0) | N/A | (0.3) | (0.0) | N/A | ||||
| XbaI SNP (C > A) † | 190 | 73 | 654 | 59 | ||||||
| CC or CA | (81.6) | (80.8) | 0.888 | 1.00 | (82.6) | (78.0) | 0.376 | 1.00 | ||
| AA | (18.4) | (19.2) | 1.05 | (0.53 - 2.09) | (17.4) | (22.0) | 1.34 | (0.70 - 2.56) | ||
*P < 0.05.
†Bonferroni correction requires p < 0.01 to reach statistical significance