Table 3.
Major Haplotype Distribution in Case and Control Subjects by Race in stage 1†‡
| European Americans | Haplotype | Promoter SNP | Intron-1 SNP1 | Intron-1 SNP2 | Enh2 SNP | XbaI SNP | Intron-2 SNP | Controls | Albuminuria Cases | P-value |
|---|---|---|---|---|---|---|---|---|---|---|
| N = 3326 Haplotypes | A | C | A | C | C | C | C | (43.4) | (39.5) | 0.773 |
| B | A | A | C | T | A | C | (17.2) | (18.9) | ||
| C | A | C | A | C | C | A | (14.1) | (14.5) | ||
| D | C | A | C | T | A | C | (6.2) | (6.8) | ||
| Others | * | * | * | * | * | * | (19.1) | (20.3) | ||
| African Americans | ||||||||||
| N = 2156 Haplotypes | A | C | A | C | C | C | C | (13.7) | (10.7) | 0.877 |
| B | A | A | C | T | A | C | (5.4) | (5.0) | ||
| C | A | C | A | C | C | A | (7.7) | (9.6) | ||
| E | C | C | C | C | C | C | (14.0) | (13.9) | ||
| F | C | C | C | C | A | C | (11.0) | (12.1) | ||
| G | A | C | C | C | A | C | (12.7) | (11.4) | ||
| H | A | C | A | C | C | C | (11.9) | (12.1) | ||
| I | A | A | C | C | A | C | (6.8) | (7.5) | ||
| Others | * | * | * | * | * | * | (16.8) | (17.5) |
‡ Major haplotypes have a frequency ≥ 5%. Minor alleles are shaded in gray. Bonferroni corrected level of statistical significance for European Americans p < 0.0125 and for African Americans p < 0.00625.
† Among European Americans, the ten diplotypes associated with the major haplotypes A, B, C, and D from table 3, only the BD diplotype was associated with albuminuria (OR 3.03, 95% CI 1.36 - 6.79, p = 0.007, compared to individuals without the BD diplotype). However, this did not reach a Bonferroni corrected level of statistical significance of p < 0.005. The diplotypes consisting of the B or D "risk" haplotypes were rare, with BB, BD, and DD diplotypes accounting for 2.7%, 2.2%, and 0.5% of the 1663 European Americans with available diplotypes analyzed.